The Effect of Aging on Nitric Oxide Production during Cerebral Ischemia and Reperfusion in Wistar Rats and Spontaneous Hypertensive Rats: An In Vivo Microdialysis Study

Nitric oxide (NO) is involved in the pathogenesis of cerebral ischemic injury. Here, we investigated effects aging on NO production during ischemia-reperfusion (IR). Male Wister rats (WRs) were assigned to 12-month-old (older; n = 5) and 3-month-old (younger; 7) groups. Similarly, male spontaneous hypertensive (SHRs) allocated 6) 8) After anesthesia, their was monitored using vivo microdialysis probes inserted into left striatum hippocampus. Forebrain IR injuries produced via ligation bilateral common carotid arteries, followed by reperfusion. The change NO3− older SHR groups less compared that younger before ischemia, after reperfusion (p < 0.05). In hippocampus, lower There no significant differences between two WR Our findings suggested SHRs affected production, especially striatum, Hypertension may be important factors impacting brain